Outcomes of Population- Based Screening
Table with Results of Published Population Based Universal Screening Studies
|
Reference |
Location |
CRC patients enrolled |
Selection |
# LS cases diagnosed |
Incidence of LS (%) |
| Barnetson et al.1 |
Scotland |
870 |
Dx <55 |
38 |
4.4 |
| Pinol et al.2 |
Spain |
1222 |
All cases |
11 |
0.9 |
| Hampel et al.3,4 |
USA |
1566 |
All cases |
44 |
2.8 |
| Cunningham et al.5 |
USA |
257 |
All cases |
7 |
2.7 |
| Salovaara et al.6 & Aaltonen et al.7 |
Finland |
1044 |
All cases |
28 |
2.7 |
1Barnetson RA, Tenesa A, Farrington SM, et al. Identification and survival of carriers of mutations in DNA mismatch-repair genes in colon cancer. N Engl J Med. 2006;354:2751-2763. [Abstract]
2Pinol V, Castells A, Andreu M, et al. Accuracy of revised Bethesda guidelines, microsatellite instability, and immunohistochemistry for the identification of patients with hereditary nonpolyposis colorectal cancer. JAMA. 2005;293:1986-1994. [Abstract]
3Hampel H, Frankel WL, Martin E, et al. Screening for the Lynch syndrome (hereditary nonpolyposis colorectal cancer). N Engl J Med. 2005;352:1851-1860. [Abstract]
4Hampel H, Frankel WL, Martin E, et al Feasibility of screening for Lynch Syndrome among patients with colorectal cancer. J Clin Oncol. 2008;26:5783-5788. [Abstract]
5Cunningham JM, Kim CY, Christensen ER, et al. The frequency of hereditary defective mismatch repair in a prospective series of unselected colorectal carcinoma. Am J Hum Genet. 2001:69:780-790. [Abstract]
6Aaltonen, LA, Salavaara R, Kristo P, et al. Incidence of hereditary nonpolyposis colorectal cancer and the feasibility of molecular screening for the disease. N Engl J Med. 1998;3389:1481-1487. [Abstract]
7Salovaara R, Loulola A, Krsito P, et al. Population –based molecular detection of hereditary nonpolyposis colorectal cancer. J Clin Oncol. 2000;18:2193-2200. [Abstract]